# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 07 May 2016: Updated by: TOUCHUP-v1.18 # molecular_function 20150225: Eukaryota_PTN000894784 has function RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 20150225: Eukaryota_PTN000894784 has function RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 20150225: Eumetazoa_PTN000894785 has function transcription coactivator activity (GO:0003713) 20150225: Eumetazoa_PTN000894785 has function transcription factor binding (GO:0008134) # cellular_component 20150225: Eukaryota_PTN000894784 is found in transcription factor complex (GO:0005667) 20150225: Eukaryota_PTN000894784 is found in nuclear chromatin (GO:0000790) # biological_process 20150225: Eukaryota_PTN000894784 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 20150225: Eukaryota_PTN000894784 participates in response to organic substance (GO:0010033) 20150225: Eukaryota_PTN000894784 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 20150225: Fungi_PTN000894808 participates in positive regulation of cellular response to amino acid starvation (GO:1903833) 20150225: Fungi_PTN000894808 participates in nitrogen catabolite activation of transcription from RNA polymerase II promoter (GO:0001080) 20150225: Eumetazoa_PTN000894785 participates in response to lipopolysaccharide (GO:0032496) 20150225: Eumetazoa_PTN000894785 participates in cellular response to hormone stimulus (GO:0032870) 20150225: Eumetazoa_PTN000894785 participates in response to radiation (GO:0009314) 20150225: Eumetazoa_PTN000894785 participates in regulation of cell proliferation (GO:0042127) 20150225: Eumetazoa_PTN000894785 participates in response to cAMP (GO:0051591) 20150225: Eumetazoa_PTN000894785 participates in regulation of cell death (GO:0010941) 20150225: Eumetazoa_PTN000894785 participates in regulation of cell cycle (GO:0051726) 20150225: Eumetazoa_PTN000894785 participates in response to cytokine (GO:0034097) 20150225: Eumetazoa_PTN000894785 participates in response to drug (GO:0042493) 20150225: Eumetazoa_PTN000894785 participates in positive regulation of cell differentiation (GO:0045597) 20150225: Eumetazoa_PTN000894785 participates in response to mechanical stimulus (GO:0009612) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: In higher eukaryotes, binds to fos to form the AP-1 transcriptional factor. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).