# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.14
24 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20110204: root_PTN000156122 has function serine-type endopeptidase inhibitor activity (GO:0004867) 
20141205: Euteleostomi_PTN000156130 has function collagen binding (GO:0005518) 

# cellular_component
20141205: root_PTN000156122 is found in extracellular space (GO:0005615) 
20141205: Euteleostomi_PTN000156130 is found in endoplasmic reticulum (GO:0005783) 
20141205: Amniota_PTN000156767 is found in cytoplasm (GO:0005737) 
20141205: Euteleostomi_PTN000156130 is NOT found in extracellular space (GO:0005615) 

# biological_process
20141205: Euteleostomi_PTN000156130 participates in collagen fibril organization (GO:0030199) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
MF
Propagated MF: GO:4867 serine endopeptidase inhibitor activity to root.
BP
Propagated GO:10951 negative regulation of endopeptidase activity and GO:30162 regulation of proteolysis to root.
CC
Most serpins are secreted; propagated to the root and fixed each clade for which this did not hold.
NOTE: Could not remove the Extracellular annotation from Amniota_PTN000156767.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).