# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20160114: root_PTN000153716 has function opioid receptor binding (GO:0031628) 20160114: root_PTN000153716 has function neuropeptide hormone activity (GO:0005184) # cellular_component 20160114: root_PTN000153716 is found in plasma membrane (GO:0005886) 20160114: root_PTN000153716 is found in extracellular region (GO:0005576) 20160114: root_PTN000153716 is found in axon terminus (GO:0043679) 20160114: root_PTN000153716 is found in neuronal cell body (GO:0043025) 20160114: root_PTN000153716 is found in dendrite (GO:0030425) # biological_process 20160114: root_PTN000153716 participates in sensory perception (GO:0007600) 20160114: root_PTN000153716 participates in neuropeptide signaling pathway (GO:0007218) 20160114: root_PTN000153716 participates in synaptic transmission (GO:0007268) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).