# HISTORY 22 Nov 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20161122: root_PTN000143677 has function unfolded protein binding (GO:0051082) 20161122: root_PTN000143677 has function protein binding involved in protein folding (GO:0044183) 20161122: Eukaryota_PTN000144086 has function 1-phosphatidylinositol-3-phosphate 5-kinase activity (GO:0000285) 20161122: Eukaryota_PTN000144086 has LOST/MODIFIED function unfolded protein binding (GO:0051082) 20161122: Eukaryota_PTN000144086 has LOST/MODIFIED function protein binding involved in protein folding (GO:0044183) 20161122: Drosophila melanogaster_FBgn0028741 has LOST/MODIFIED function protein binding involved in protein folding (GO:0044183) 20161122: Drosophila melanogaster_FBgn0028741 has LOST/MODIFIED function unfolded protein binding (GO:0051082) # cellular_component 20161122: Bacteria _PTN000143644 is found in cytosol (GO:0005829) 20161122: Methanosarcina acetivorans_Q8TGX7 is NOT found in mitochondrion (GO:0005739) 20161122: cellular organisms_PTN000143507 is found in cytosol (GO:0005829) 20161122: Eukaryota_PTN000144020 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000143755 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000144086 is found in cytoplasm (GO:0005737) 20161122: Eukaryota_PTN000143937 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000144200 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000143681 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000144135 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN002260199 is NOT found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000144020 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000143755 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000144086 is found in cytoplasm (GO:0005737) 20161122: Eukaryota_PTN000143937 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000144200 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000143681 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000144135 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000143848 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000144283 is found in chaperonin-containing T-complex (GO:0005832) 20161122: Eukaryota_PTN000144086 is found in endosome membrane (GO:0010008) 20161122: Fungi_PTN000887441 is found in fungal-type vacuole membrane (GO:0000329) 20161122: Euteleostomi_PTN000144289 is found in ciliary basal body (GO:0036064) 20161122: Euteleostomi_PTN002260323 is found in autophagosome (GO:0005776) 20161122: Euteleostomi_PTN002260323 is NOT found in chaperonin-containing T-complex (GO:0005832) 20161122: Euteleostomi_PTN002260323 is found in lysosome (GO:0005764) 20161122: Euteleostomi_PTN002260323 is found in late endosome (GO:0005770) 20161122: Drosophila melanogaster_FBgn0028741 is NOT found in chaperonin-containing T-complex (GO:0005832) 20161122: node_PTN001683765 is found in chloroplast (GO:0009507) 20161122: Magnoliophyta_PTN001683766 is NOT found in mitochondrion (GO:0005739) 20161122: Pentapetalae_PTN001683443 is found in chloroplast (GO:0009507) 20161122: Bacteria _PTN000143644 is found in GroEL-GroES complex (GO:1990220) 20161122: node_PTN000143639 is found in mitochondrion (GO:0005739) 20161122: node_PTN000888029 is found in mitochondrion (GO:0005739) 20161122: Magnoliophyta_PTN001683766 is NOT found in mitochondrion (GO:0005739) # biological_process 20161122: root_PTN000143677 participates in protein folding (GO:0006457) 20161122: Eukaryota_PTN000144086 does NOT participate in protein folding (GO:0006457) 20161122: Eukaryota_PTN000144086 participates in phosphatidylinositol phosphorylation (GO:0046854) 20161122: Eukaryota_PTN000144086 participates in retrograde transport, endosome to Golgi (GO:0042147) 20161122: Chordata_PTN001347162 participates in regulation of autophagosome assembly (GO:2000785) 20161122: Euteleostomi_PTN000144289 participates in cilium assembly (GO:0060271) 20161122: Euteleostomi_PTN002260323 participates in plus-end-directed vesicle transport along microtubule (GO:0072383) 20161122: Euteleostomi_PTN002260323 participates in positive regulation of autophagosome maturation (GO:1901098) 20161122: Drosophila melanogaster_FBgn0028741 does NOT participate in protein folding (GO:0006457) 20161122: Eukaryota_PTN000143508 participates in protein import into mitochondrial intermembrane space (GO:0045041) 20161122: Amoebozoa_PTN000143588 does NOT participate in apoptotic mitochondrial changes (GO:0008637) 20161122: Alveolata_PTN000143591 does NOT participate in apoptotic mitochondrial changes (GO:0008637) 20161122: Stramenopiles_PTN001683761 does NOT participate in apoptotic mitochondrial changes (GO:0008637) 20161122: Excavarus_PTN000888080 does NOT participate in apoptotic mitochondrial changes (GO:0008637) 20161122: Viridiplantae_PTN000143631 does NOT participate in apoptotic mitochondrial changes (GO:0008637) 20161122: Opisthokonta_PTN000143510 participates in apoptotic mitochondrial changes (GO:0008637) 20161122: Euteleostomi_PTN000143514 participates in T cell activation (GO:0042110) 20161122: Euteleostomi_PTN000143514 participates in regulation of cytokine production (GO:0001817) 20161122: Pentapetalae_PTN001683443 participates in chloroplast organization (GO:0009658) 20161122: Methanosarcina acetivorans_Q8TGX7 does NOT participate in mitochondrion organization (GO:0007005) 20161122: Magnoliophyta_PTN001683766 does NOT participate in mitochondrion organization (GO:0007005) 20161122: node_PTN000888029 participates in mitochondrion organization (GO:0007005) 20161122: Magnoliophyta_PTN001683766 does NOT participate in mitochondrion organization (GO:0007005) 20161122: root_PTN000143677 participates in chaperone-mediated protein folding (GO:0061077) 20161122: root_PTN000143677 participates in 'de novo' protein folding (GO:0006458) 20161122: Eukaryota_PTN000144086 does NOT participate in 'de novo' protein folding (GO:0006458) 20161122: Eukaryota_PTN000144086 does NOT participate in chaperone-mediated protein folding (GO:0061077) 20161122: Drosophila melanogaster_FBgn0028741 does NOT participate in 'de novo' protein folding (GO:0006458) 20161122: Drosophila melanogaster_FBgn0028741 does NOT participate in chaperone-mediated protein folding (GO:0061077) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).