# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.14
24 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20141029: root_PTN000139394 has function G-protein coupled receptor activity (GO:0004930) 
20141029: root_PTN000139394 has function Wnt-activated receptor activity (GO:0042813) 
20141029: root_PTN000139394 has function Wnt-protein binding (GO:0017147) 
20141029: Eumetazoa_PTN000885245 has function patched binding (GO:0005113) 
20141029: Eumetazoa_PTN000885245 has LOST/MODIFIED function Wnt-activated receptor activity (GO:0042813) 

# cellular_component
20141029: root_PTN000139394 is found in integral component of membrane (GO:0016021) 

# biological_process
20141030: root_PTN000139394 participates in non-canonical Wnt signaling pathway (GO:0035567) 
20141029: root_PTN000139394 participates in canonical Wnt signaling pathway (GO:0060070) 
20141029: Eumetazoa_PTN000885245 participates in smoothened signaling pathway (GO:0007224) 
20141030: Eumetazoa_PTN000885245 does NOT participate in non-canonical Wnt signaling pathway (GO:0035567) 
20141029: Eumetazoa_PTN000885245 does NOT participate in canonical Wnt signaling pathway (GO:0060070) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Frizzled/smoothened family. It contains all 10 members of Frizzled, smoothened and 5 member of secreted frizzled related protein (sFRP).
MF- GPCRs. It is interesting that only the smoothened has the annotation of GPCR. Propagate to the root, but have to stop at the sFRPs clades.
BP - most tems are indirect so they are not propagated. SMO may regulate wnt pathway, but it is not part of the wnt pathway, so put a stop to the clade.
sFRPs are involved in wnt pathway as a negative regulator.
Curated on Oct. 29, 2014 - HM

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).