# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20131125: Eumetazoa_PTN000885159 has function ephrin receptor binding (GO:0046875) 

# cellular_component
20131125: Eumetazoa_PTN000885159 is found in plasma membrane (GO:0005886) 
20131205: Euteleostomi_PTN000139122 is found in anchored component of plasma membrane (GO:0046658) 
20131205: Euteleostomi_PTN000139180 is found in anchored component of plasma membrane (GO:0046658) 

# biological_process
20131205: Eumetazoa_PTN000885159 participates in ephrin receptor signaling pathway (GO:0048013) 
20131206: Eumetazoa_PTN000885159 participates in axon guidance (GO:0007411) 
20140211: Euteleostomi_PTN000139151 participates in cell migration (GO:0016477) 
20140211: Euteleostomi_PTN000139151 participates in blood vessel morphogenesis (GO:0048514) 
20140211: Euteleostomi_PTN000139122 participates in regulation of actin cytoskeleton organization (GO:0032956) 
20140211: Euteleostomi_PTN000139122 participates in regulation of cell-cell adhesion (GO:0022407) 
20140211: Euteleostomi_PTN000139251 participates in bone remodeling (GO:0046849) 
20140211: Euteleostomi_PTN000139251 participates in osteoclast differentiation (GO:0030316) 
20140211: Euteleostomi_PTN000139180 participates in angiogenesis (GO:0001525) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
ephrins also known as ephrin ligands or eph family receptor interacting proteins are a family of proteins that serve as the ligands of the ephrin receptor. ephrin receptors in turn compose the largest known subfamily of receptor protein-tyrosine kinases.
Since ephrin ligands (ephrins) and Eph receptors (Ephs) are both membrane-bound proteins, binding and activation of Eph/epherin intracellular signaling pathways can only occur via direct cell-cell interaction. Eph/epherin signaling regulates a variety of biological processes during embryonic development including the guidance of axon growth cones, formation of tissue boundaries, cell migration, and segmentation. Additionally, Eph/epherin signaling has recently been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation, angiogenesis, and stem cell differentiation.
Ephrin ligands are divided into two subclasses of ephrin-A and ephrin-B based on their structure and linkage to the cell membrane. Ephrin-As are anchored to the membrane by a glycosylphosphatidylinositol (GPI) linkage and lack a cytoplasmic domain while ephrin-Bs are attached to the membrane by a single transmembrane domain that contains a short cytoplasmic PDZ-binding motif.
Of the eight ephrins that have been identified in humans there are five known ephrin-A ligands (ephrin-A1-5) that interact with nine EphAs (EphA1-8 and EphA10) and three ephrin-B ligands (ephrin-B1-3) that interact with five EphBs (EphB1-4 and EphB6).
PMID: 11870224 shows EphA3-expressing cell show morphological changes such as membrane blebbing. In contrast to apoptotic blebbs, which are static and often detach from the cell surface, ephrin-A5 triggers highly dynamic, spherical membrane protrusions that do not lead to cell fragmentation.
Challenged the old annotations of not to 'execution phase of apoptosis' GO:0097194, challenge accepted.
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# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).