# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20131122: root_PTN000135648 has function protein homodimerization activity (GO:0042803) 
20131122: root_PTN000135648 has function protein heterodimerization activity (GO:0046982) 
20131126: Deuterostomia_PTN000883418 has function channel activity (GO:0015267) 

# cellular_component
20131122: root_PTN000135648 is found in mitochondrial outer membrane (GO:0005741) 

# biological_process
20131126: root_PTN000135648 participates in intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) 
20131126: root_PTN000135648 participates in extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192) 
20131126: Bilateria_PTN000135647 participates in negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) 
20131125: Bilateria_PTN000883416 participates in positive regulation of apoptotic process (GO:0043065) 
20131126: Deuterostomia_PTN000883418 participates in release of cytochrome c from mitochondria (GO:0001836) 
20131126: Deuterostomia_PTN000883418 participates in mitochondrial fusion (GO:0008053) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
this is a bcl 2 family, including bcl-2, and its related protein, bax, bak, and bok. all of them contains bh domain and are capable of forming homodimers or heterodimers. so for mf, propagate protein homodimerization and heterodimerization activities.
Bax also has channel activities on the mitochondrial membrane, so propagate it to the orthologue group ancestor node.
For CC, propagate mitochondrail outer membrane to the root.
For BP, Bax and Bak ositively regulate apoptosis, while Bcl-2 related proteins negatively regulate. The mechanism for Bok is not clear. So propagate accordingly.
Bax is directly involved in cytochrome release, and is propagated.
Bak is not directly involved. The cited paper indicated its role in cytochrome release, but probably not directly. Therefore, it is not propagated.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).