# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.14
24 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20110204: root_PTN000134256 has function ubiquitin-protein transferase activity (GO:0004842) 

# cellular_component
20120413: root_PTN000134256 is found in cytoplasm (GO:0005737) 
20120413: root_PTN000134256 is found in nucleus (GO:0005634) 

# biological_process
20110204: root_PTN000134256 participates in protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) 
20120413: Bilateria_PTN000135002 participates in transforming growth factor beta receptor signaling pathway (GO:0007179) 
20120413: Ecdysozoa_PTN000134947 participates in lipid storage (GO:0019915) 
20120413: Diptera_PTN000134951 participates in Notch signaling pathway (GO:0007219) 
20120413: Euteleostomi_PTN000134682 participates in androgen receptor signaling pathway (GO:0030521) 
20120413: Euteleostomi_PTN000134824 participates in progesterone receptor signaling pathway (GO:0050847) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
MF: propagated ubq-protein ligase to root
CC: propagated cytoplasm and nucleus to root because many proteins show both localizations and these are consistent with the location of the proteasome
BP: propagated ubiquitin-dependent proteolysis to root, propagated all pathway annotations (AR pathway UBE3A clade, vertebrates; PR pathway UBR5 clade, vertebrates; Notch pathway Su(dx) clade, insects; lipid storage Su(dx) clade, ecdysozoa because annotated in both fly and worm; TGFbeta pathway lack/SMURF1,2 clade) except glucocorticoid for NEDD4 as paper appears to use a heterologous system

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).