# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140312: Eukaryota_PTN001343361 has function phosphatidate phosphatase activity (GO:0008195) 20140312: Eukaryota_PTN000133932 has function thiolester hydrolase activity (GO:0016790) 20140312: Eumetazoa_PTN000882372 has function palmitoyl-(protein) hydrolase activity (GO:0008474) 20140312: Eukaryota_PTN000134048 has function dolichyldiphosphatase activity (GO:0047874) # cellular_component 20140312: root_PTN000133931 is found in intracellular membrane-bounded organelle (GO:0043231) 20140312: Eukaryota_PTN001343361 is found in chloroplast (GO:0009507) 20140312: Eukaryota_PTN000133932 is found in lysosome (GO:0005764) 20140312: Eukaryota_PTN000134048 is found in integral component of endoplasmic reticulum membrane (GO:0030176) 20140312: Viridiplantae_PTN000882335 is found in chloroplast (GO:0009507) 20140312: Viridiplantae_PTN000134034 is NOT found in lysosome (GO:0005764) 20140312: Eukaryota_PTN001343395 is NOT found in lysosome (GO:0005764) # biological_process 20140312: Eukaryota_PTN001343361 participates in diacylglycerol biosynthetic process (GO:0006651) 20140312: Eumetazoa_PTN000882372 participates in protein depalmitoylation (GO:0002084) 20140312: Eumetazoa_PTN000882372 participates in receptor-mediated endocytosis (GO:0006898) 20140312: Mammalia_PTN000133985 participates in synaptic transmission (GO:0007268) 20140312: Mammalia_PTN000133985 participates in nervous system development (GO:0007399) 20140312: Eukaryota_PTN000134048 participates in protein N-linked glycosylation (GO:0006487) 20140312: Eukaryota_PTN000134048 participates in lipid biosynthetic process (GO:0008610) 20140312: Viridiplantae_PTN000882335 participates in diacylglycerol biosynthetic process (GO:0006651) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES - PPRT2 does not depalmitoylate proteins; see PMID 12855696. Requested GO terms to capture hydrolysis of palmitoyl, see https://sourceforge.net/p/geneontology/ontology-requests/10705/ - Stopped propagation of "lysosome" for plants since plants do not have lysosomes. PG 2014-03-12 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).