# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.14
24 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150319: root_PTN000129805 has function ubiquitin protein ligase activity (GO:0061630) 
20150319: root_PTN000129805 has function cullin family protein binding (GO:0097602) 
20150319: Eukaryota_PTN000129806 has function NEDD8 transferase activity (GO:0019788) 

# cellular_component
20150319: root_PTN000129805 is found in cullin-RING ubiquitin ligase complex (GO:0031461) 
20150319: Eukaryota_PTN000129916 is found in anaphase-promoting complex (GO:0005680) 
20150319: Eukaryota_PTN000129806 is found in Cul2-RING ubiquitin ligase complex (GO:0031462) 
20150319: Eukaryota_PTN000129806 is found in Cul7-RING ubiquitin ligase complex (GO:0031467) 
20150319: Eukaryota_PTN000129806 is found in Cul4-RING E3 ubiquitin ligase complex (GO:0080008) 
20150319: Eukaryota_PTN000129806 is found in Cul3-RING ubiquitin ligase complex (GO:0031463) 
20150319: Eukaryota_PTN000129806 is found in nuclear SCF ubiquitin ligase complex (GO:0043224) 
20150319: Eumetazoa_PTN000879788 is found in Cul5-RING ubiquitin ligase complex (GO:0031466) 

# biological_process
20150319: root_PTN000129805 participates in protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) 
20150319: Eukaryota_PTN000129916 participates in positive regulation of mitotic metaphase/anaphase transition (GO:0045842) 
20150319: Eukaryota_PTN000129806 participates in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146) 
20150319: Eukaryota_PTN000129806 participates in protein neddylation (GO:0045116) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
SF Ontology request: #11587

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).