# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150723: Theria _PTN000111938 has function high-density lipoprotein particle binding (GO:0008035) 20150723: Theria _PTN000111938 has function lipase inhibitor activity (GO:0055102) 20150723: Theria _PTN000111938 has function high-density lipoprotein particle receptor binding (GO:0070653) 20150723: Theria _PTN000111938 has function cholesterol binding (GO:0015485) 20150723: Theria _PTN000111938 contributes to function cholesterol transporter activity (GO:0017127) 20150723: Theria _PTN000111938 has function phosphatidylcholine binding (GO:0031210) 20150723: Theria _PTN000111938 has function apolipoprotein receptor binding (GO:0034190) # cellular_component 20150723: Theria _PTN000111938 is found in spherical high-density lipoprotein particle (GO:0034366) 20150723: Theria _PTN000111938 is found in chylomicron (GO:0042627) 20150723: Theria _PTN000111938 is found in very-low-density lipoprotein particle (GO:0034361) 20150723: Theria _PTN000111938 is found in blood microparticle (GO:0072562) # biological_process 20150723: Theria _PTN000111938 participates in high-density lipoprotein particle assembly (GO:0034380) 20150723: Theria _PTN000111938 participates in negative regulation of lipase activity (GO:0060192) 20150723: Theria _PTN000111938 participates in triglyceride-rich lipoprotein particle remodeling (GO:0034370) 20150723: Theria _PTN000111938 participates in low-density lipoprotein particle remodeling (GO:0034374) 20150723: Theria _PTN000111938 participates in high-density lipoprotein particle remodeling (GO:0034375) 20150723: Theria _PTN000111938 participates in cholesterol homeostasis (GO:0042632) 20150723: Theria _PTN000111938 participates in lipoprotein metabolic process (GO:0042157) 20150723: Theria _PTN000111938 participates in cholesterol metabolic process (GO:0008203) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).