# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150814: root_PTN000111102 has function glyoxalase III activity (GO:0019172) 20150814: node_PTN000111103 has function transcription coactivator activity (GO:0003713) 20150814: node_PTN001664538 has function transcription regulatory region DNA binding (GO:0044212) 20150814: node_PTN000111187 has function transcription factor activity, sequence-specific DNA binding (GO:0003700) 20150814: node_PTN000111187 has function core promoter proximal region sequence-specific DNA binding (GO:0000987) 20150814: node_PTN001664538 has LOST/MODIFIED function glyoxalase III activity (GO:0019172) 20150814: node_PTN000111187 has LOST/MODIFIED function glyoxalase III activity (GO:0019172) # cellular_component 20150814: node_PTN000111103 is found in mitochondrion (GO:0005739) 20150814: node_PTN000111103 is found in nucleus (GO:0005634) 20150814: node_PTN000111103 is found in cytosol (GO:0005829) 20150814: node_PTN000744423 is found in cytosol (GO:0005829) 20150814: Bacteria _PTN000111171 is NOT found in mitochondrion (GO:0005739) 20150814: Bacteria _PTN000111171 is NOT found in nucleus (GO:0005634) # biological_process 20150814: root_PTN000111102 participates in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione (GO:0019243) 20150814: node_PTN000111103 participates in regulation of transcription from RNA polymerase II promoter (GO:0006357) 20150814: node_PTN000111103 participates in cellular response to hydrogen peroxide (GO:0070301) 20150814: node_PTN001664538 participates in regulation of transcription, DNA-templated (GO:0006355) 20150814: node_PTN000111187 participates in regulation of transcription, DNA-templated (GO:0006355) 20150814: node_PTN001664538 does NOT participate in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione (GO:0019243) 20150814: node_PTN000111187 does NOT participate in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione (GO:0019243) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).