# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20160108: root_PTN001663160 is found in extracellular space (GO:0005615) # biological_process 20160108: root_PTN001663160 participates in multicellular organism reproduction (GO:0032504) 20160108: root_PTN001663160 participates in circadian rhythm (GO:0007623) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED ## Annotations that have been removed. 20160108: root_PTN001663160 to behavior (GO:0007610) is an excluded term and not to be used for annotation # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).