# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.14 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140605: node_PTN001333297 has function tRNA threonylcarbamoyladenosine dehydratase (GO:0061503) 20140605: Eukaryota_PTN000102296 has function UFM1 activating enzyme activity (GO:0071566) 20140606: cellular organisms_PTN000102041 has function small protein activating enzyme activity (GO:0008641) 20140605: Eukaryota_PTN001333314 has function FAT10 activating enzyme activity (GO:0019780) 20140606: Eukaryota_PTN000102175 has function NEDD8 activating enzyme activity (GO:0019781) 20140605: Eukaryota_PTN000102239 has function SUMO activating enzyme activity (GO:0019948) 20140606: Eukaryota_PTN000102043 has function SUMO activating enzyme activity (GO:0019948) 20140605: Eukaryota_PTN000102341 has function Atg12 activating enzyme activity (GO:0019778) 20140605: Eukaryota_PTN000102341 has function Atg8 activating enzyme activity (GO:0019779) 20140606: Eukaryota_PTN000102114 has function NEDD8 activating enzyme activity (GO:0019781) 20140605: Eukaryota_PTN000102404 has function ubiquitin activating enzyme activity (GO:0004839) 20140605: Eukaryota_PTN000102404 has function ubiquitin-protein transferase activity (GO:0004842) 20140605: Mammalia_PTN000102413 has function ISG15 activating enzyme activity (GO:0019782) 20140606: Eukaryota_PTN000102535 has function URM1 activating enzyme activity (GO:0042292) 20140605: Eukaryota_PTN000102535 has function protein adenylyltransferase activity (GO:0070733) 20140605: Eukaryota_PTN000102535 has function thiosulfate sulfurtransferase activity (GO:0004792) 20140605: Bacteria _PTN000102608 has function zinc ion binding (GO:0008270) 20140605: Bacteria _PTN000102608 has function ATP binding (GO:0005524) 20140605: Bacteria _PTN000102608 has function magnesium ion binding (GO:0000287) 20140605: Bacteria _PTN000102608 has function nucleotidyltransferase activity (GO:0016779) # cellular_component 20140605: root_PTN000102039 is found in cytosol (GO:0005829) 20140605: Eukaryota_PTN000102175 is found in nucleus (GO:0005634) 20140605: Eukaryota_PTN000102239 is found in SUMO activating enzyme complex (GO:0031510) 20140605: Eukaryota_PTN000102043 is found in nucleus (GO:0005634) 20140605: Eukaryota_PTN000102342 is found in pre-autophagosomal structure (GO:0000407) 20140605: Eukaryota_PTN000102114 is found in nucleus (GO:0005634) 20140605: Eukaryota_PTN000102404 is found in nucleus (GO:0005634) # biological_process 20140605: node_PTN001333297 participates in cyclic threonylcarbamoyladenosine biosynthetic process (GO:0061504) 20140605: Eukaryota_PTN000102296 participates in protein ufmylation (GO:0071569) 20140606: node_PTN000102040 participates in cellular protein modification process (GO:0006464) 20140605: cellular organisms_PTN000102041 participates in protein modification by small protein conjugation (GO:0032446) 20140605: Eukaryota_PTN001333314 participates in ubiquitin-dependent protein catabolic process (GO:0006511) 20140605: Eukaryota_PTN000102175 participates in protein neddylation (GO:0045116) 20140605: Eukaryota_PTN000102239 participates in protein sumoylation (GO:0016925) 20140605: Eukaryota_PTN000102043 participates in regulation of mitotic cell cycle (GO:0007346) 20140605: Eukaryota_PTN000102043 participates in protein sumoylation (GO:0016925) 20140605: Eukaryota_PTN000102341 participates in macroautophagy (GO:0016236) 20140605: Eukaryota_PTN000102341 participates in piecemeal microautophagy of nucleus (GO:0034727) 20140605: Eukaryota_PTN000102341 participates in mitophagy (GO:0000422) 20140605: Eukaryota_PTN000102341 participates in late nucleophagy (GO:0044805) 20140605: Eukaryota_PTN000102341 participates in cellular response to nitrogen starvation (GO:0006995) 20140605: Eukaryota_PTN000102341 participates in C-terminal protein lipidation (GO:0006501) 20140605: Eukaryota_PTN000102341 participates in protein catabolic process (GO:0030163) 20140605: Eukaryota_PTN000102114 participates in protein neddylation (GO:0045116) 20140606: Eukaryota_PTN000102404 participates in modification-dependent protein catabolic process (GO:0019941) 20140605: Mammalia_PTN000102413 participates in ISG15-protein conjugation (GO:0032020) 20140605: Eukaryota_PTN000102535 participates in protein urmylation (GO:0032447) 20140605: Eukaryota_PTN000102535 participates in tRNA wobble position uridine thiolation (GO:0002143) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES First node PTN001333297 should be separated and put in another family tree. Mitochondrial location: Do not propagate; only large scale evidences. MAF 2014-06-06 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).