# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150603: root_PTN000101945 has function lipoate synthase activity (GO:0016992) # cellular_component 20150603: Opisthokonta_PTN000101948 is found in mitochondrion (GO:0005739) 20150603: node_PTN001658267 is found in chloroplast (GO:0009507) 20150603: Bacteria _PTN000102019 is found in cytoplasm (GO:0005737) # biological_process 20150603: root_PTN000101945 participates in protein lipoylation (GO:0009249) 20150603: root_PTN000101945 participates in lipoate biosynthetic process (GO:0009107) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).