# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150319: node_PTN000101302 has function glutamine-fructose-6-phosphate transaminase (isomerizing) activity (GO:0004360) 20150319: Bacteria _PTN000101410 has LOST/MODIFIED function glutamine-fructose-6-phosphate transaminase (isomerizing) activity (GO:0004360) # cellular_component 20150319: Bacteria _PTN000101436 is found in cytosol (GO:0005829) # biological_process 20150327: node_PTN000101302 participates in UDP-N-acetylglucosamine metabolic process (GO:0006047) 20150319: node_PTN000101302 participates in fructose 6-phosphate metabolic process (GO:0006002) 20150319: Fungi_PTN000859305 participates in fungal-type cell wall chitin biosynthetic process (GO:0034221) 20150327: Bacteria _PTN000101410 does NOT participate in UDP-N-acetylglucosamine metabolic process (GO:0006047) 20150319: Bacteria _PTN000101410 does NOT participate in fructose 6-phosphate metabolic process (GO:0006002) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MF: based on pmid:16408321, "Cys1, Glu591, His607 and Lys707" as catalytic residues in CANAL, these residues are well conserved, except in the blocked nodes and nodes PTN001333018 and PTN000859374. BP: propagations were based on the function propagation. N-linked glycosylation involves UDP-N-acetylglucosamine, so this term was propagated. Similarly, UDP-N-acetylglucosamine is involved in chitin synthesis in fungi. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).