# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150819: cellular organisms_PTN000100321 has function RNA methyltransferase activity (GO:0008173) 20150819: Eukaryota_PTN000100455 has function rRNA (uridine-2'-O-)-methyltransferase activity (GO:0008650) 20150819: Eukaryota_PTN000100323 has function tRNA methyltransferase activity (GO:0008175) 20150819: Eukaryota_PTN000100393 has function rRNA (guanine) methyltransferase activity (GO:0016435) 20150819: Eukaryota_PTN000100393 has function rRNA (uridine-2'-O-)-methyltransferase activity (GO:0008650) # cellular_component 20150819: Eukaryota_PTN000100456 is found in mitochondrion (GO:0005739) 20150819: Eukaryota_PTN000858779 is found in cytosol (GO:0005829) 20150819: Eukaryota_PTN000100323 is found in cytoplasm (GO:0005737) 20150819: Eukaryota_PTN000100393 is found in nucleolus (GO:0005730) 20150819: Eukaryota_PTN000100393 is found in preribosome, large subunit precursor (GO:0030687) # biological_process 20150819: cellular organisms_PTN000100321 participates in RNA methylation (GO:0001510) 20150819: Eukaryota_PTN000100455 participates in enzyme-directed rRNA 2'-O-methylation (GO:0000453) 20150819: Eukaryota_PTN000100323 participates in tRNA methylation (GO:0030488) 20150819: Eukaryota_PTN000100323 participates in cytoplasmic translation (GO:0002181) 20150819: Eukaryota_PTN000100393 participates in rRNA methylation (GO:0031167) 20150819: Eukaryota_PTN000100393 participates in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000463) 20150819: Eukaryota_PTN000100393 participates in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000466) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).