# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140820: Opisthokonta_PTN000855676 has function cell adhesion molecule binding (GO:0050839) # cellular_component 20140820: root_PTN000096377 is found in extracellular space (GO:0005615) 20140820: Dikarya_PTN000855771 is found in fungal-type vacuole membrane (GO:0000329) 20140820: Opisthokonta_PTN000855676 is found in proteinaceous extracellular matrix (GO:0005578) 20140820: Bacteria _PTN000096537 is found in outer membrane-bounded periplasmic space (GO:0030288) # biological_process 20140820: Dikarya_PTN000855771 participates in macroautophagy (GO:0016236) 20140820: Opisthokonta_PTN000855676 participates in cell adhesion (GO:0007155) 20140820: Opisthokonta_PTN000855676 participates in extracellular matrix organization (GO:0030198) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Shown to be vacuolar in 2 fungi and a clear function in autophagosome-vacuole fusion is shown S. pombe but no evidence for cell-cell-adhesion function, even if large scale proteomics shows extracellular location in Aspergillus nidulans. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).