# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.14
24 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20130206: node_PTN000093539 has function calcium channel activity (GO:0005262) 

# cellular_component
20130206: node_PTN000093539 is found in membrane (GO:0016020) 

# biological_process
20130206: node_PTN000093539 participates in detection of mechanical stimulus (GO:0050982) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
For MF:
-DENN domain, ancient conserved across species from yeast, evolved together with the RAB GTPases, for which they are regulators
-Checked elegans, and several other proteins across this group, most proteins are described as having the DENN domain so was comfortable propagating Rab guanyl-nucleotide exchange factor activity (GO:0017112) to the common ancestor, Bilateria-PTN000093542, i.e all of the family of DENN proteins
(DENN Domain Proteins: Regulators of Rab GTPases, PMID:21330364)
-For the rest of the tree, which includes the Polycystins and the TRP (Transient Receptor Potential) channel proteins:
-Propagated calcium channel activity (GO:0005262) all the way to PO, i.e the entire tree, because the proteins at the bottom of the tree, Phythopthora and Chlamydomonas have proteins that are consistantly described as Polycystins, including them would include proteins from the top of the tree, not described very well, but still comfortable with this propagation.
-Added NOT for the calcium channel activity (GO:0005262) to the common ancestor of the DENN domain proteins, Bilateria-PTN000093542.
For CC:
Propagated 'membrane' all the way to PO, because the proteins are either channels, or GTPase activators.
For BP:
-Propagated detection of mechanical stimulus (GO:00050982) all the way till ANO, seems to be a common cellular level process across the polycystins, in evolution. Many papers describe the function of polycsytins and TRP proteins as mechanosensors in the cilia.
-Did not see any evidence that the DENN domain proteins, which are RAB GTPase activators, are involved in detection of mechanical stimulus, so added a NOT-detection of mechanical stimulus to the common ancestor of the DENN domain proteins.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).