# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.14 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function # cellular_component 20120328: root_PTN000093238 is found in cytosol (GO:0005829) 20120328: root_PTN000093238 is found in small ribosomal subunit (GO:0015935) 20120328: Eukaryota_PTN000093341 is NOT found in cytosol (GO:0005829) # biological_process 20110127: root_PTN000093238 participates in ribosome biogenesis (GO:0042254) 20120328: root_PTN000093238 participates in translation (GO:0006412) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MF: propagated only term (structural constituent of ribosome) to root CC: duplication in eukaryotes appears to correspond to cytosol vs. mitochondrion/chloroplast, inferred cytosol at root because this would have been the CC in LUCA, and then loss of cytosol and gain of mitochondrion in the SWS2 clade. Note RPS10A and B in yeast are annotated with mitochondrion from a high-throughput paper-- did not propagate these as they disagree with annotations of orthologs and with the gene summaries from SGD. BP: Propagated translation to root, ribosome biogenesis to root because the yeast RPS18 genes are annotated to child terms of ribosome biogenesis (rRNA export and rRNA processing). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).