# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 07 May 2016: Updated by: TOUCHUP-v1.18 # molecular_function 20150818: root_PTN000090975 has function calcium channel activity (GO:0005262) 20150818: root_PTN000090975 has function potassium ion binding (GO:0030955) 20150818: root_PTN000090975 has function calcium, potassium:sodium antiporter activity (GO:0008273) 20150818: root_PTN000090975 has function calcium ion binding (GO:0005509) 20150818: root_PTN000090975 has function sodium ion binding (GO:0031402) # cellular_component 20150818: root_PTN000090975 is found in integral component of plasma membrane (GO:0005887) 20150818: Chordata_PTN000851839 is NOT found in integral component of plasma membrane (GO:0005887) # biological_process 20150818: root_PTN000090975 participates in cellular calcium ion homeostasis (GO:0006874) 20150818: Euteleostomi_PTN000091012 participates in sensory perception of smell (GO:0007608) 20150818: Chordata_PTN000851795 participates in long term synaptic depression (GO:0060292) 20150818: Chordata_PTN000851795 participates in long-term synaptic potentiation (GO:0060291) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).