# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140916: Opisthokonta_PTN000085799 has function delta24(24-1) sterol reductase activity (GO:0000246) # cellular_component # biological_process 20140916: Eukaryota_PTN000085798 participates in steroid metabolic process (GO:0008202) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MF: Propagated GO:246, the granular term, to the specific clade because it is not clear if this activity is present in plants and bacteria. Progagted the parent term to plants and bacteria. The protein sequences in this family show high degree of a similarity. CC: There are manual annotations to various locations in the cell. Propagated membrane and cytoplasm only to be conservative. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).