# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.14 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140730: Eukaryota_PTN000084083 has function 3'-5'-exoribonuclease activity (GO:0000175) 20140730: Eukaryota_PTN000084084 has function poly(A)-specific ribonuclease activity (GO:0004535) # cellular_component 20140730: Eukaryota_PTN000084083 is found in CCR4-NOT complex (GO:0030014) # biological_process 20140730: Eukaryota_PTN000084083 participates in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES The transcription factor activity term was not propagated because it was made using TAS and tracing the original papers did not provide convincing evidence to propagate this term. The yeast POP2 gene has a positive and NOT annotation to the MF term 3',5' exoribonuclease. Examining the literature revealed that the positive annotation to 3',5' exoribonuclease was made based on an invitro assay of a fragment of the protein (IDA). The IGI and IMP are more convincing annotations. But overall several other genes in the family are annotated to this activity and hence it looks like this function is conserved all the way. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).