# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20141114: Eukaryota_PTN000079486 is found in COP9 signalosome (GO:0008180) 20141114: Eukaryota_PTN000079540 is found in proteasome regulatory particle, lid subcomplex (GO:0008541) # biological_process 20141114: root_PTN000079485 participates in ubiquitin-dependent protein catabolic process (GO:0006511) 20141114: Eukaryota_PTN000079486 participates in cullin deneddylation (GO:0010388) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES The root could be annotated to 'GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process' but the term is not available; meawhile, annotated to 'ubiquitin-dependent protein catabolic process (GO:0006511)', but that should be removed once the regulation term is available. PG 2014-11-14. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).