# HISTORY 04 Aug 2016: Updated by: TOUCHUP-v1.21 # molecular_function 20160428: Eukaryota_PTN000068843 has function adenylate cyclase binding (GO:0008179) 20160428: Eukaryota_PTN000068843 has function actin binding (GO:0003779) # cellular_component 20160428: Eukaryota_PTN000068843 is found in cortical actin cytoskeleton (GO:0030864) # biological_process 20160428: Eukaryota_PTN000068843 participates in actin polymerization or depolymerization (GO:0008154) 20160428: Eukaryota_PTN000068843 participates in establishment or maintenance of cell polarity (GO:0007163) 20160428: Eukaryota_PTN000068843 participates in signal transduction (GO:0007165) 20160428: Eukaryota_PTN000068843 participates in regulation of adenylate cyclase activity (GO:0045761) 20160428: Eukaryota_PTN000068843 participates in cell morphogenesis (GO:0000902) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).