# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20140914: Eukaryota_PTN000068525 has function mRNA binding (GO:0003729) 20140914: Eukaryota_PTN000068363 has function damaged DNA binding (GO:0003684) 20140915: Eukaryota_PTN000068443 has function RNA binding (GO:0003723) # cellular_component 20140914: root_PTN000068362 is found in nucleus (GO:0005634) 20140914: Eukaryota_PTN000068526 is found in mRNA cleavage and polyadenylation specificity factor complex (GO:0005847) 20140915: Eukaryota_PTN000068363 is found in cullin-RING ubiquitin ligase complex (GO:0031461) # biological_process 20140914: Eukaryota_PTN000068525 participates in mRNA cleavage (GO:0006379) 20140914: Eukaryota_PTN000068525 participates in mRNA polyadenylation (GO:0006378) 20140915: Eukaryota_PTN000068363 participates in proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 20140915: Eukaryota_PTN000068363 participates in nucleotide-excision repair (GO:0006289) 20140914: Eukaryota_PTN000068443 participates in mRNA splicing, via spliceosome (GO:0000398) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).