# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20150331: cellular organisms_PTN000066877 has function tRNA (guanine-N2-)-methyltransferase activity (GO:0004809) 20150331: Deuterostomia_PTN000066953 has LOST/MODIFIED function tRNA (guanine-N2-)-methyltransferase activity (GO:0004809) # cellular_component 20150331: cellular organisms_PTN000066877 is found in nucleus (GO:0005634) 20150331: cellular organisms_PTN000066877 is found in mitochondrion (GO:0005739) 20150331: Deuterostomia_PTN000066953 is NOT found in nucleus (GO:0005634) 20150331: Deuterostomia_PTN000066953 is NOT found in mitochondrion (GO:0005739) 20150331: Archaea_PTN000066980 is NOT found in nucleus (GO:0005634) 20150331: Archaea_PTN000066980 is NOT found in mitochondrion (GO:0005739) # biological_process 20150331: cellular organisms_PTN000066877 participates in tRNA N2-guanine methylation (GO:0002940) 20150331: Deuterostomia_PTN000066953 does NOT participate in tRNA N2-guanine methylation (GO:0002940) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).