# HISTORY
03 Jun 2016: Saved by pascalegaudet using Paint 2.0-beta19
02 Jun 2016: Saved by pascalegaudet using Paint 2.0-beta19

# molecular_function
20160602: Eukaryota_PTN000061616 has function ion channel activity (GO:0005216) 
20160602: Opisthokonta_PTN000832860 has function calcium channel activity (GO:0005262) 

# cellular_component
20160602: Eukaryota_PTN000061616 is found in integral component of plasma membrane (GO:0005887) 
20160602: Dikarya_PTN001317340 is NOT found in integral component of plasma membrane (GO:0005887) 
20160603: Euteleostomi_PTN000061707 is found in cilium (GO:0005929) 

# biological_process
20160602: Euteleostomi_PTN000061707 participates in cellular hypotonic response (GO:0071476) 
20160602: Euteleostomi_PTN000061707 participates in osmosensory signaling pathway (GO:0007231) 
20160602: Euteleostomi_PTN000061707 participates in actin filament organization (GO:0007015) 
20160603: Euteleostomi_PTN000061707 participates in cellular calcium ion homeostasis (GO:0006874) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED
## Annotations that have been removed.
20160602: Eukaryota_PTN000061616 to calcium ion transport into cytosol (GO:0060402)  using [RGD:628841, RGD:620636] - lacks supporting evidence
20160602: Dikarya_PTN001317340 to fungal-type vacuole membrane (GO:0000329)  using [SGD:S000005613] - lacks supporting evidence
20160602: Dikarya_PTN001317340 to calcium activated cation channel activity (GO:0005227)  using [SGD:S000005613] - lacks supporting evidence
20160602: Euteleostomi_PTN000061707 to cell-cell junction assembly (GO:0007043)  using [MGI:MGI:1926945] - lacks supporting evidence
20160602: Euteleostomi_PTN000061707 to cellular response to heat (GO:0034605)  using [MGI:MGI:1926945] - lacks supporting evidence

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).