# HISTORY 04 Aug 2016: Updated by: TOUCHUP-v1.21 # molecular_function 20160428: Eukaryota_PTN000058080 has function actin filament binding (GO:0051015) # cellular_component 20160428: Eukaryota_PTN000058080 is found in filamentous actin (GO:0031941) 20160428: Eukaryota_PTN000058080 is found in cytoplasm (GO:0005737) 20160428: Tetrapoda_PTN000058113 is found in filopodium (GO:0030175) 20160428: Tetrapoda_PTN000058113 is found in growth cone (GO:0030426) 20160428: Tetrapoda_PTN000058113 is found in cell projection membrane (GO:0031253) 20160428: Tetrapoda_PTN000058113 is found in microvillus (GO:0005902) 20160428: Tetrapoda_PTN000058113 is found in lamellipodium (GO:0030027) 20160428: Tetrapoda_PTN000058113 is found in ruffle (GO:0001726) # biological_process 20160428: Eukaryota_PTN000058080 participates in actin filament bundle assembly (GO:0051017) 20160428: Eukaryota_PTN000058080 participates in cell migration (GO:0016477) 20160428: Eukaryota_PTN000058080 participates in establishment or maintenance of cell polarity (GO:0007163) 20160428: Opisthokonta_PTN000830735 participates in anatomical structure morphogenesis (GO:0009653) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).