# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20140925: Chordata_PTN000829823 has function G-protein coupled receptor binding (GO:0001664) 20140919: Chordata_PTN000829823 has function hormone activity (GO:0005179) 20140919: node_PTN000056513 has function neuropeptide hormone activity (GO:0005184) # cellular_component 20140925: Chordata_PTN000829823 is found in extracellular space (GO:0005615) # biological_process 20140925: Chordata_PTN000829823 participates in cell-cell signaling (GO:0007267) 20140919: node_PTN000056513 participates in neuropeptide signaling pathway (GO:0007218) 20140925: node_PTN000056513 participates in regulation of appetite (GO:0032098) 20140919: node_PTN000056513 participates in feeding behavior (GO:0007631) 20140919: Euteleostomi_PTN000056539 participates in digestion (GO:0007586) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).