# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
18 Nov 2015: redistribution of PTN001121516 from PTHR22964 to PTHR10489
18 Nov 2015: redistribution of PTN000661678 from PTHR24236 to PTHR10489
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20150414: Diptera_PTN001201583 has function neuropeptide receptor activity (GO:0008188) 
20150414: Diptera_PTN000661585 has function allatostatin receptor activity (GO:0008261) 
20150414: Diptera_PTN000661678 has function leucokinin receptor activity (GO:0042071) 
20140306: Bilateria_PTN001491415 has function actin filament binding (GO:0051015) 

# cellular_component
20140306: Bilateria_PTN001491415 is found in Z disc (GO:0030018) 

# biological_process
20150414: Diptera_PTN001201583 participates in neuropeptide signaling pathway (GO:0007218) 
20140306: Euteleostomi_PTN000539684 participates in smooth muscle contraction (GO:0006939) 
20140306: Euteleostomi_PTN000539684 participates in positive regulation of cell migration (GO:0030335) 
20140306: Eumetazoa_PTN001121516 participates in regulation of apoptotic process (GO:0042981) 
20150414: Diptera_PTN000661585 participates in neuropeptide signaling pathway (GO:0007218) 
20140306: Bilateria_PTN001491415 participates in regulation of cell migration (GO:0030334) 
20140306: Bilateria_PTN001491415 participates in regulation of cytoskeleton organization (GO:0051493) 
20140306: Bilateria_PTN001491415 participates in cardiac muscle fiber development (GO:0048739) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
-Annotated MYLK clade (Bilateria_PTN001491415) to regulation of cell migration (GO:0030334) rather than cell motility because the evidence for the Zebrafish paper describes cell migration (athough they use cell motitity in the text as well).
- Annotated Bilateria_PTN000539674 to actin filament organization (GO:0007015) and myosin light chain kinase activity (GO:0004687) because those two annotations support each other.
*ISSUES*
- Cannot propagate autophagy: not annotated in the DAPK clade, and the only annotated protein is a fly protein but annotating to a common ancestor would lead to annotating the entire tree.
- DAPK2 is downstream from TOR (see PMID: 21690574); the GO term 'TOR signaling' does not exactly describe this.
- Proteins with roles in muscle function (Drosophila sqa; human NEXN) are too distant to be used for annotating ancestors.
PG 2014-05-08

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).