# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20150814: root_PTN000046327 has function hydrolase activity, acting on ester bonds (GO:0016788) # cellular_component 20150814: root_PTN000046327 is found in endoplasmic reticulum (GO:0005783) 20150814: root_PTN000046327 is found in membrane (GO:0016020) 20150814: Pentapetalae_PTN001625546 is found in vacuolar membrane (GO:0005774) 20150814: Bacteria _PTN000046466 is NOT found in endoplasmic reticulum (GO:0005783) # biological_process # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).