# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20140731: root_PTN000045225 has function O-acyltransferase activity (GO:0008374) 20140731: node_PTN000045308 has function cholesterol O-acyltransferase activity (GO:0034736) 20140731: Fungi_PTN000823393 has function ergosterol O-acyltransferase activity (GO:0034737) 20140731: Eukaryota_PTN000045226 has function diacylglycerol O-acyltransferase activity (GO:0004144) # cellular_component 20140731: root_PTN000045225 is found in endoplasmic reticulum membrane (GO:0005789) 20140731: Embryophyta_PTN000823449 is found in chloroplast envelope (GO:0009941) # biological_process 20140731: Eumetazoa_PTN000823452 participates in cholesterol metabolic process (GO:0008203) 20140731: Fungi_PTN000823393 participates in ergosterol metabolic process (GO:0008204) 20140731: Eukaryota_PTN000045226 participates in triglyceride biosynthetic process (GO:0019432) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES O-acyltransferase activity was transferred to the root node because it looks like each clade specialized to perform this function for a different substrate (yeast doesn't make cholesterol, but makes ergosterol). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).