# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20140225: root_PTN000042665 has function NADH dehydrogenase (ubiquinone) activity (GO:0008137) 

# cellular_component
20140225: root_PTN000042665 is found in plasma membrane respiratory chain complex I (GO:0045272) 
20140225: Eukaryota_PTN000042666 is found in mitochondrial respiratory chain complex I (GO:0005747) 
20140225: Eukaryota_PTN001623575 is NOT found in plasma membrane respiratory chain complex I (GO:0045272) 
20140225: Euryarchaeota_PTN001623574 is NOT found in plasma membrane respiratory chain complex I (GO:0045272) 
20140225: Eukaryota_PTN000042666 is NOT found in plasma membrane respiratory chain complex I (GO:0045272) 

# biological_process
20140225: root_PTN000042665 participates in respiratory electron transport chain (GO:0022904) 
20140225: Eukaryota_PTN000042666 participates in mitochondrial electron transport, NADH to ubiquinone (GO:0006120) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Notes Two clades related by duplication at root.  One clade has no annotations; infer most general molecular function (NADH dehydrogenase).  For other clade, clearly involved in respiratory electron chain ancestrally, operating on ubiquinone (see EcoCyc nuoE); originally in plasma membrane, then in eukaryotes in mitochondrial membrane.  For molecular function, infer electron carrier (function) as well as dehydrogenase (mechanism).
PT Nov2013

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).