# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20140924: Opisthokonta_PTN000818648 has function protein kinase binding (GO:0019901) 20140924: Eumetazoa_PTN000818658 has function receptor tyrosine kinase binding (GO:0030971) # cellular_component 20140924: Eumetazoa_PTN000818649 is found in centrosome (GO:0005813) 20140924: Eumetazoa_PTN000818658 is found in plasma membrane (GO:0005886) # biological_process 20140924: Eumetazoa_PTN000818649 participates in centriole replication (GO:0007099) 20140924: Eumetazoa_PTN000818658 participates in transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 20140924: Euteleostomi_PTN000037387 participates in epidermal growth factor receptor signaling pathway (GO:0007173) 20140924: Tetrapoda_PTN000037430 participates in epidermal growth factor receptor signaling pathway (GO:0007173) 20140924: Tetrapoda_PTN000037430 participates in activation of MAPK activity (GO:0000187) 20140924: Tetrapoda_PTN000037430 participates in insulin receptor signaling pathway (GO:0008286) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).