# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20120413: root_PTN000027918 has function S-methyl-5-thioribose-1-phosphate isomerase activity (GO:0046523) 
20110128: cellular organisms_PTN000027920 has function guanyl-nucleotide exchange factor activity (GO:0005085) 
20120413: cellular organisms_PTN000027920 has LOST/MODIFIED function S-methyl-5-thioribose-1-phosphate isomerase activity (GO:0046523) 

# cellular_component
20120413: root_PTN000027918 is found in cytoplasm (GO:0005737) 
20120413: cellular organisms_PTN000027920 is found in eukaryotic translation initiation factor 2B complex (GO:0005851) 

# biological_process
20120413: root_PTN000027918 participates in L-methionine biosynthetic process from methylthioadenosine (GO:0019509) 
20110128: cellular organisms_PTN000027920 participates in regulation of translational initiation (GO:0006446) 
20110128: Eukaryota_PTN000027922 participates in negative regulation of translational initiation (GO:0045947) 
20120413: cellular organisms_PTN000027920 does NOT participate in L-methionine biosynthetic process from methylthioadenosine (GO:0019509) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
MF
Propagated both GO:5085, guanyl-nucleotide exchange factor activity and to duplication node creating EIF2B1, EIF2B2 and EIF2B4 clades. Did not propagate translation initiation factor activity as technically this is a GEF that acts on EIF2 to regulate its translation factor activity, and does not directly possess this activity itself.  Propagated GO:46523, S-methyl-5-thioribose-1-phosphate isomerase activity to root, as it is clearly ancestral (it is found in the EI2BL clade in eukaryotes as well as the bacterial outgroup, see PMID:14551435 for the B. subtilis mtnA protein.  This function was apparently lost in the EIF GEF clade.
CC
Propagated GPO:5851, eukaryotic translation initiation factor 2B complex to PNTHR10233_AN2. Note that this should be changed to eukaryotic-archaeal EIF complex as it is also apparently found in archaea (PMID:21265752).  Propagated cytoplasm to root.  Did not propagate nucleus annotation of MRI1 or plasmodesma annotation of AT2G05830 as they are from a HT experiments.
BP
Propagated GO:6446, regulation of translation initiation to PNTHR10233_AN2 (as well as loss of L-met salvage) and GO:19509, L-methionine salvage from methylthioadenosine to root.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).