# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function # cellular_component 20140609: Eumetazoa_PTN001305081 is found in mitochondrion (GO:0005739) # biological_process # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES . Phylogeny Small family. Some members don't seem to belong (ENSCING00000001256, XP_00186645). Gallus sequence seems broken into 2 (XP_001233315 and XP_001236570) MF No propagabale terms. CC Propagated mitochondria to eukaryotes (AN1) and cytoplasm to prokaryotes (AN60) BP The data are not strong enough for propagation. =Questions for MOD curators= ==Cellular Component== ===Mouse=== * '''Critical''': [http://www.informatics.jax.org/searches/accession_report.cgi?id=mgi:1351861 D10Jhu81e] has a CC component annotation to "centriole" based on PMID 18239929, which seems to refer to a completely different gene. I think the problem arose from the fact that the [http://www.uniprot.org/uniprot/P30042 human ortholog] of D10Jhu81e has the synonym GT335, which is also the name of an [http://www.enzolifesciences.com/ALX-804-885/polyglutamylation-modification-mab-gt335/ anti-tubulin antibody] used in this paper. Can you please have a look ? **'''Curator answer:''' Correction made in MGI. PG 12 Jan 2011 MSL 22 Mar 2011, updated Due to the tree update, the paint curation was not ofrwardly tracked. Therefore, the tree was recurated. No MF term. BP terms are for e. coli, so they are not propagated. Propagate mitochondrion to PTN001305081, but not PTN000812468 because most of the sequences are fragments or uncharacterized under that node. Updated on June 9 2014 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).