# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.12 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20130819: root_PTN000025348 has function voltage-gated potassium channel activity (GO:0005249) 20130819: node_PTN000025935 has function intracellular cAMP activated cation channel activity (GO:0005222) 20130819: node_PTN000025935 has function intracellular cGMP activated cation channel activity (GO:0005223) 20130819: node_PTN000025935 has function cGMP binding (GO:0030553) # cellular_component 20130819: root_PTN000025348 is found in integral component of plasma membrane (GO:0005887) # biological_process 20130819: root_PTN000025348 participates in regulation of membrane potential (GO:0042391) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).