# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.12
24 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20110114: Eukaryota_PTN000022879 has function GTPase activator activity (GO:0005096) 

# cellular_component
20110114: Eukaryota_PTN000022879 is found in intrinsic component of the cytoplasmic side of the plasma membrane (GO:0031235) 
20110114: Eukaryota_PTN000022879 is found in cytoplasm (GO:0005737) 

# biological_process
20110114: Eukaryota_PTN000022879 participates in negative regulation of Ras protein signal transduction (GO:0046580) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Fast-pass curation of PTHR10194 (RAS GTPase-activating proteins) family
Review: PMID: 15246431
MF:
Propagate GO:0005099 Ras GTPase activator activity to AN1 based on widespread annotations.
Human RASA4, with manual annotation to GO:0005096 GTPase activator activity, consider update it to GO:0005099 Ras GTPase activator activity based on PMID:11448776. Same with mouse Nf1 based on PMID:15665300
Human RASA3, need to justify it�s GO: calcium-release channel activity annotation, probably also need to add BP annotation.
CC:
Propagate GO:0031235 intrinsic to internal side of plasma membrane and GO:0005737 cytoplasm to AN1 based on existing annotation and information from the review article PMID: 15246431.
- Ignore SGD GO:0005739 mitochondrion HTP annotation
- Also ignore human RASA2 GO:0043231 intracellular membrane-bounded organelle. HTP annotation, PMID:18029348
- Questioning GO:0005634 nucleus annotation from rat and mouse.
PMID: 1550670 RGD Nf1, In most neurons, staining was not obviously localized to the plasma membrane or the cell nucleus, suggesting a primarilycytoplasmic localization for the antigen (Figure 5B). However, in a few cells nuclear staining was observed (Figure 5C). The apparent nuclear staining could be due to enhanced staining in the perinuclear region or nonspecific staining of damaged cells.
PMID: 8306889 mouse Nf1, delete GO:0005634 nucleus annotation. It�s about mouse Nfia, �nuclear factor I� .
-PMID:11356864 RGD Nf1neurofibromin to be distributed widely in neurons, including axons, dendrites, and cell bodies� Will not propagate these cell type specific annotations at the moment.
BP:
Propagate GO:0032320 �positive regulation of Ras GTPase activity� and GO:0046580 �negative regulation of Ras protein signal transduction� to AN1 based on existing annotations.
Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of consequent Ras-mediated biological responses. Will not  propagate those consequent Ras-mediated biological responses  annotations at the moment.
LN, 14 Jan 2011

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).