# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20110112: Chordata_PTN000019045 has function transcription factor binding (GO:0008134) 

# cellular_component
20110112: Euteleostomi_PTN000019046 is found in cytoplasm (GO:0005737) 
20110120: Euteleostomi_PTN000019046 is found in nucleus (GO:0005634) 

# biological_process
20110112: Euteleostomi_PTN000019046 participates in animal organ development (GO:0048513) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Curation of PTHR10170 (HUNTINGTIN) family
Phylogeny
Small family. Phylogeny seems okay. Last common ancestor with data is AN4, conservation is poor outside that so this is the earlier branch to which annotations were propagated.
References
http://en.wikipedia.org/wiki/Huntingtin
MF
Propagated transcription factor binding to AN4. Did not propagate calcium channel regulation (see question to RGD).
CC
Propagated 'cytoplasm' to AN4.
Propagated nucleus to AN4.
20 Jan 2011: Added nucleus annotation to AN4 based on new annotations from GOA.
BP
Propagated the term 'organ development' to AN4. It may be possible to be a bit more specific about neural system development but zebra fish htt is annotated to neural plate formation and mouse to brain development, and those two terms have no link in the ontology.
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=Questions for MOD curators=
==Molecular Function==
===Rat===
*'''Question:''' Can you check the annotation to 'calcium channel regulator activity' based on PMID 14570907. The data seem to indicate an aberrant role of the protein when mutated, and in my opinion the results cannot be used to infer the role of the WT protein.
**'''Curator answer: '''The annotation has been deleted.  Thank you for finding this error.
===Human===
*Human(?) should annotate this [http://jcs.biologists.org/cgi/content/full/115/5/941 paper].
**'''Curator answer: ''' This paper (PMID:11870213) mostly contains data for mouse and rat HTT (beta-tubulin binding, microtubule binding, centrosome). I have added an annotation to beta-tubulin binding for human HTT.
PG, 12 Jan 2011
Updated 20 Jan 2011, PG
Questions updated 21 Mar 2011, ML

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).