# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20110103: root_PTN000018846 has function DNA topoisomerase type II (ATP-hydrolyzing) activity (GO:0003918) 

# cellular_component
20140530: root_PTN000018846 is found in DNA topoisomerase complex (ATP-hydrolyzing) (GO:0009330) 
20120402: root_PTN000018846 is found in nucleoid (GO:0009295) 
20140530: Eukaryota_PTN000018888 is found in nucleus (GO:0005634) 
20120402: Eukaryota_PTN000018888 is NOT found in nucleoid (GO:0009295) 

# biological_process
20110103: root_PTN000018846 participates in DNA topological change (GO:0006265) 
20140530: root_PTN000018846 participates in DNA unwinding involved in DNA replication (GO:0006268) 
20110103: root_PTN000018846 participates in chromosome segregation (GO:0007059) 
20110103: Eukaryota_PTN000018888 participates in sister chromatid segregation (GO:0000819) 
20110103: Eukaryota_PTN000018888 participates in mitotic recombination (GO:0006312) 
20110103: Eukaryota_PTN000018888 participates in resolution of meiotic recombination intermediates (GO:0000712) 
20110103: Eukaryota_PTN000018888 participates in mitotic DNA integrity checkpoint (GO:0044774) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Phylogeny
This family consists of 2 main paralogous clades: a primarily bacterial gyrA outgroup with a small plant clade, and a larger gyrB/TOP2 clade that spans bacteria through humans.  gyrB proteins are bacterial, and TOP2 proteins (including the paralogous vertebrate TOP2A and 2B subclades) are eukaryotic.
MF
-GO:0003918 "DNA topoisomerase (ATP-hydrolyzing) activity" is widespread.  Propagate to root.  Note that Arabidopsis GYRB3 has both positive and negative annotations to this term.
CC
- Propagate "nucleoid " to root
- Propagate "nucleus" to eukaryotic TOP2 clade.
- Ignore annotations to mitochondria and chloroplast; they're all HTP.
BP
-Propagate GO:0006265 "DNA topological change" to root.
-GO:0007059 "chromosome segregation" is widespread.  Propagate to root.  More specific terms may follow.
-GO:0070683 "mitotic cell cycle G2/M transition decatenation checkpoint": Propagate to eukaryotes. TOP2's to reflect role of Topo II in sister chromatid segregation.  Same for GO:0000819 "sister chromatid segregation" and GO:0006312 "mitotic recombination."
-Same for GO:GO:0000712 "resolution of meiotic recombination intermediates" in meiosis.
Fast-pass curation  MSL 3 Jan 2011
Reviewed PG 2014-05-30

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).