# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 07 May 2016: Updated by: TOUCHUP-v1.18 # molecular_function 20150210: Bilateria_PTN000018365 has function calcium channel regulator activity (GO:0005246) # cellular_component 20150210: Bilateria_PTN000018365 is found in voltage-gated calcium channel complex (GO:0005891) # biological_process 20150210: Bilateria_PTN000018365 participates in calcium ion transmembrane transport (GO:0070588) 20150210: Bilateria_PTN000018365 participates in regulation of calcium ion transport (GO:0051924) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES The family contains mainly voltage dependent calcium channel subunit alpha2/delta family members. Because these proteins contain von Willbrand factor A domain, it brought in some additional proteins that contain such domain. There is no evidence suggesting that those proteins have calcium transport activity. From MSA, the only area that are aligned are the VWFA domain. Therefore all the propagations are up to the billateral node of the CACNA2D node. MF: Many members are annotated as "voltage dependent calcium channel activity", but this subunit is a regulatory one that is not part of the pore. This term is not propagated. Only the regulator term is propagated. Feb. 10, 2015, HM # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).