# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20121007: root_PTN000015587 has function heme binding (GO:0020037) 
20121007: root_PTN000015587 has function tryptophan 2,3-dioxygenase activity (GO:0004833) 

# cellular_component

# biological_process
20121007: root_PTN000015587 participates in tryptophan catabolic process to acetyl-CoA (GO:0019442) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Phylogeny is fairly simple, and there are no likely duplications aside from teleosts.
Propagate MF heme binding and trp dioxygenase to root, as well as BP pathway trp to acetyl-coA, as these are likely to belong to entire group (verified that this pathway is present in prokaryotes as well by consulting metaCyc http://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=TRPCAT-PWY, and all paths lead to acetyl-coA production). Do not propagate amino acid binding or oxygen binding or trp metabolic process as these are implied by trp dioxygenase activity. Propagate BP ommochrome biosynthesis to insects as this appears to be the phylogenetic range of this term (invertebrate eye), and trp to kyl is the first step for all ommochromes.
PDT
07 Oct 2012

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).