# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.12 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150728: Eukaryota_PTN001604757 has function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) # cellular_component 20150728: Eukaryota_PTN001604757 is found in nucleus (GO:0005634) # biological_process 20150728: Eukaryota_PTN001604757 participates in regulation of transcription from RNA polymerase II promoter (GO:0006357) 20150728: Mammalia_PTN000014690 participates in lens fiber cell differentiation (GO:0070306) 20150728: Amniota_PTN001604769 participates in regulation of rhodopsin gene expression (GO:0007468) 20150728: Amniota_PTN001604769 participates in retinal rod cell development (GO:0046548) 20150728: Tetrapoda_PTN000014661 participates in nervous system development (GO:0007399) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).