# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.12
24 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150212: Eukaryota_PTN000012230 has function store-operated calcium channel activity (GO:0015279) 

# cellular_component
20150212: Eukaryota_PTN000012230 is found in integral component of plasma membrane (GO:0005887) 

# biological_process
20150212: Eukaryota_PTN000012230 participates in manganese ion transport (GO:0006828) 
20150212: Eukaryota_PTN000012230 participates in regulation of cytosolic calcium ion concentration (GO:0051480) 
20150212: Bilateria_PTN001298123 participates in single fertilization (GO:0007338) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains members from the TRPC superfamily of TRP family. They are non-selective cation channels that are permeable to Ca, Na and Mg. They are involved in releasing internal Ca stores to the cytosol.
There are some problems with the annotation in this family.
1. It is annotated to Ca channel activity. This is not correct. In the field of physiology, a Ca channel means a channel selectively permeable to Ca. This channel is a non-selective channel. It can be annotated to Cation channel in MF and Ca transport in BP.
2. Two fly genes are annotated to lighted-induced voltage-gated Ca channel, which is incorrect. The reference used in the annotations clearly states that these channels are not voltage gated. A dispute was sent to protein2go.
Feb. 12, 2015, HM

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).