# HISTORY
23 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20130308: Eukaryota_PTN000005955 has function 1-phosphatidylinositol-3-kinase activity (GO:0016303) 
20130308: Eukaryota_PTN000005893 has function 1-phosphatidylinositol 4-kinase activity (GO:0004430) 
20130308: Eukaryota_PTN000005674 has function 1-phosphatidylinositol-3-kinase activity (GO:0016303) 
20130308: Eukaryota_PTN000005674 has function 1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005) 
20130308: Bilateria_PTN000799658 has function phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 
20130308: Bilateria_PTN000005743 has function phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 
20130308: Eukaryota_PTN000006021 has function 1-phosphatidylinositol 4-kinase activity (GO:0004430) 

# cellular_component
20130308: Eukaryota_PTN000005955 is found in phosphatidylinositol 3-kinase complex (GO:0005942) 
20130308: Eukaryota_PTN000005893 is found in cytoplasm (GO:0005737) 
20130308: Eukaryota_PTN000005674 is found in plasma membrane (GO:0005886) 
20130308: Eukaryota_PTN000005674 is found in phosphatidylinositol 3-kinase complex (GO:0005942) 
20130308: Eukaryota_PTN000006021 is found in plasma membrane (GO:0005886) 

# biological_process

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains four subfamilies:
Eukaryota_PTN000006021; PI4K
Eukaryota_PTN000005674 (multiple duplications within this subfamily); PI3K
Eukaryota_PTN000005955; PI3K
Eukaryota_PTN000005893; PI4K
Molecuar Function:
1) GO:0004430 1-phosphatidylinositol 4-kinase activity: found in human, rat, fly, yeast and Arabidopsis, propagate to PTN000006021 and PTN000005893
2) GO:0016303 1-phosphatidylinositol-3-kinase activity: well conserved within this clade, propagate to PTN000005674 and PTN000005955
3) GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity. propagate to PTN000005674 and PTN000005955 based on annotations to DROME_Pi3K92E, rat PiK3C2g, human PiK3C2A, human PIK3C2B, DROME_Pi3K68D.
4) GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity. Two proteins are annotated to this term: DROME_Pi3K59F and human_PIK3CA. Propagate to bilateria_PTN000005743 based on the fly annotation and bilateria_PTN000799658 based on the human annotation.
Did not propagate the binding terms.
Cellular Component:
Examined by subfamilies:
1) Eukaryota_PTN000006021; PI4K: propagate 'plasma membrane' to the root of this clade based on IDA annotations to yeast ATT4 and plant ATPI4K.
2) Eukaryota_PTN000005674; PI3K: annotations to 'plasma membrane' and 'cytoplasm/cytosol'  are widespread, propagate 'plasma membrane', 'cytoplasm' to the root fo this clade. Also propagate 'phosphatidylinositol 3-kinase complex' to the root of this clade.
3) Eukaryota_PTN000005955; PI3K: annotation to 'cytoplasm/cytosol' is widespread, progagate 'cytoplasm' to the root of this clade. Also propagate 'phosphatidylinositol 3-kinase complex' to the root based on annotation to its three child terms (phosphatidylinositol 3-kinase complex I, II, III). Did not propagate the annotation to 'membrane' since this is based on IMP (SCHPO_pik3).
4) Eukaryota_PTN000005893; PI4K: annotation to 'cytoplasm/cytosol' is widespread, progagate 'cytoplasm' to the root of this clade. Did not propagate 'nucleus' - the Arabidopsis annotation is based on high throughput assay.
Biological Process:
The PAINT curator has not yet curated BP annotations for this family.
Annotated by Donghui Li on 03/08/2013.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).