# HISTORY 23 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20130909: Boreoeutheria_PTN000004112 has function complement binding (GO:0001848) # cellular_component 20130909: node_PTN000004098 is found in extracellular region (GO:0005576) 20130909: Boreoeutheria_PTN000004112 is found in cell surface (GO:0009986) 20130909: Boreoeutheria_PTN000004112 is found in plasma membrane (GO:0005886) # biological_process 20130909: node_PTN000004098 participates in cell activation (GO:0001775) 20130909: Boreoeutheria_PTN000004112 participates in cell surface receptor signaling pathway (GO:0007166) 20130909: Boreoeutheria_PTN000004112 participates in regulation of complement activation (GO:0030449) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family only presents in animals. MF: - complement binding: propagate to PTN4112. BP: - regulation of complement activation: propagate to PTN4112. - cell surface receptor signaling pathway: propagate to PTN4112. - cell activation: propagate to PTN4098. CC: - cell surface, plasma membrane: propagate to PTN4112. - extracellular region: propagate to PTN4098. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).