# HISTORY
23 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function

# cellular_component
20130906: Embryophyta_PTN000798582 is found in vacuole (GO:0005773) 

# biological_process

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Members of this family encode alpha-L-fucosidase. This gene is widely present in many species.
MF:
- alpha-L-fucosidase activity: propagate to the root,
- 1,6-alpha-L-fucosidase activity: did not propagate, without diving deep into the literature, I chose to propagate the parent term 'alpha-L-fucosidase activity' instead. This parent term is widely annotated to many gene products in this family.
- carbohydrate binding: not propagated.
- fucose binding: propagate to the root.
BP:
- glycosaminoglycan catabolic process: NAS annotation to only 1 gene product, not propagated.
- glycoprotein catabolic process: TAS annotation to Arabidopsis FUC1, not propagated.
- carbohydrate metabolic process and fucose metabolic process: MF term already capture the information. Did not propagate.
- glycoside catabolic process: NAS annotation to Rat Fuca1, did not propagate.
CC:
- lysosome: propagate to Eukaryota PTN798519.
- vacuole: propagate to plants: PTN798582.
Annotation issues:
HypF is also shown to have carbamoyl-phosphate phosphatase activity [PMID:12377778].
References:
PMID:9118002
PMID:12586941
PMID:12377778

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).