# HISTORY
23 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20130905: node_PTN000003017 has function carboxyl- or carbamoyltransferase activity (GO:0016743) 
20130905: node_PTN000003017 has function zinc ion binding (GO:0008270) 
20130905: node_PTN000003030 has function acylphosphatase activity (GO:0003998) 

# cellular_component

# biological_process
20130906: node_PTN000003017 participates in protein maturation (GO:0051604) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family has a acylphosphatase clade (represented by DROME_Acyp, Acyp2) and a hydrogenase maturation protein HypF clade (represented by E. coli hypF) as a result of an early duplication at the root (PTN_000003016). These two clades may have evolved into different functions. Acylphosphatase (E.C. 3.6.1.7) is one of the smallest enzymes known (11,365 Da for the horse muscle form). It catalyses the hydrolysis of acylphosphates, compounds containing a carboxylphosphate bond such as 1,3-bisphosphoglycerate, carbamoylphosphate, succinylphosphate, acetylphosphate and beta aspartylphosphate [PMID:9118002]. It is present in organs and tissues of vertebrate species as two isoenzymes sharing over 55% of sequence homology; these appear highly conserved in differing species [PMID:9118002, see duplication after PTN_000003037]. HypF is a carbamoyltransferase that transfers the carbamoyl moiety of carbamoyladenylate to the COOH-terminal cysteine of HypE (another hydrogenase maturation protein) [PMID:12586941]. HypF is also shown to have carbamoyl-phosphate phosphatase activity [PMID:12377778].
MF:
Propagate 'acylphosphatase activity' to PTN3030; 'carboxyl- or carbamoyltransferase activity' and 'zion ion binding' to PTN3017.
BP:
Propagate 'protein maturation' to PTN3017.
'protein carbamoylation' 'phosphate-containing compound metabolic process' - these two single-step process terms were not propagated.
CC:
No terms propagated.
Annotation issues:
HypF is also shown to have carbamoyl-phosphate phosphatase activity [PMID:12377778].
References:
PMID:9118002
PMID:12586941
PMID:12377778

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).