# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
23 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12
07 May 2016: Updated by: TOUCHUP-v1.18

# molecular_function
20141117: root_PTN000001283 has function calcium-dependent phospholipid binding (GO:0005544) 
20141117: root_PTN000001283 has function calcium ion binding (GO:0005509) 
20141117: node_PTN000001285 has function syntaxin binding (GO:0019905) 
20141117: node_PTN000001285 has function clathrin binding (GO:0030276) 
20141117: Tetrapoda_PTN000001864 has function phosphatidylinositol-4,5-bisphosphate binding (GO:0005546) 
20141117: Bilateria_PTN000001972 has LOST/MODIFIED function calcium-dependent phospholipid binding (GO:0005544) 
20141117: Bilateria_PTN000001972 has LOST/MODIFIED function calcium ion binding (GO:0005509) 
20141117: Eumetazoa_PTN000797547 has LOST/MODIFIED function calcium-dependent phospholipid binding (GO:0005544) 
20141117: Euteleostomi_PTN000001654 has LOST/MODIFIED function syntaxin binding (GO:0019905) 
20141117: Euteleostomi_PTN000001654 has LOST/MODIFIED function clathrin binding (GO:0030276) 
20141117: Euteleostomi_PTN000001677 has LOST/MODIFIED function syntaxin binding (GO:0019905) 
20141117: Euteleostomi_PTN000001677 has LOST/MODIFIED function clathrin binding (GO:0030276) 
20141117: Euteleostomi_PTN000002099 has LOST/MODIFIED function syntaxin binding (GO:0019905) 
20141117: Euteleostomi_PTN000002099 has LOST/MODIFIED function clathrin binding (GO:0030276) 

# cellular_component
20141117: root_PTN000001283 is found in plasma membrane (GO:0005886) 
20141117: Eumetazoa_PTN000797746 is found in exocytic vesicle (GO:0070382) 
20141117: Bilateria_PTN000740739 is found in synaptic vesicle membrane (GO:0030672) 

# biological_process
20141117: node_PTN000001285 participates in calcium ion-regulated exocytosis of neurotransmitter (GO:0048791) 
20141117: node_PTN000001285 participates in vesicle fusion (GO:0006906) 
20141117: node_PTN000001285 participates in regulation of calcium ion-dependent exocytosis (GO:0017158) 
20141117: Bilateria_PTN000740739 participates in synaptic vesicle endocytosis (GO:0048488) 
20141117: Bilateria_PTN000001972 does NOT participate in regulation of calcium ion-dependent exocytosis (GO:0017158) 
20141117: Eumetazoa_PTN000797547 does NOT participate in calcium ion-regulated exocytosis of neurotransmitter (GO:0048791) 
20141117: Eumetazoa_PTN000797547 does NOT participate in regulation of calcium ion-dependent exocytosis (GO:0017158) 
20141117: Euteleostomi_PTN000001654 does NOT participate in calcium ion-regulated exocytosis of neurotransmitter (GO:0048791) 
20141117: Euteleostomi_PTN000001654 does NOT participate in vesicle fusion (GO:0006906) 
20141117: Euteleostomi_PTN000001654 does NOT participate in regulation of calcium ion-dependent exocytosis (GO:0017158) 
20141117: Euteleostomi_PTN000001485 does NOT participate in calcium ion-regulated exocytosis of neurotransmitter (GO:0048791) 
20141117: Euteleostomi_PTN000001485 does NOT participate in regulation of calcium ion-dependent exocytosis (GO:0017158) 
20141117: Euteleostomi_PTN000001677 does NOT participate in calcium ion-regulated exocytosis of neurotransmitter (GO:0048791) 
20141117: Euteleostomi_PTN000001677 does NOT participate in vesicle fusion (GO:0006906) 
20141117: Euteleostomi_PTN000001677 does NOT participate in regulation of calcium ion-dependent exocytosis (GO:0017158) 
20141117: Euteleostomi_PTN000002099 does NOT participate in vesicle fusion (GO:0006906) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
1. There are a few C2CD proteins in the middle of the tree. These proteins contain C2 domain that are shared among all Syt proteins. Functionally they do not share any function with the Syt members except for Ca binding.
2. A paper (PMID:17190793) shows that Syt12 does not bind to Ca and is not involved in Ca dependent exocytosis.
Nov. 17, 2014 - HM
This family was checked into svn in Feb. 2015, but it should be recurated once the paint software is updated, because some of the NOT annotations are not properly done due to the tool problem. See emails and PAINT call minutes back in November for details.
Feb. 12, 2015, HM

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).